You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You should also talk about the risks and benefits of not treating your condition. Your healthcare provider will want to see you often while you are taking the combination of dextromethorphan and bupropion, especially at the beginning of your treatment. A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Research indicates that Bupropion’s dual action creates a synergistic effect in treating co-occurring depression and nicotine dependence. Studies have shown positive outcomes in individuals using Bupropion as part of their smoking cessation plan while also managing depressive symptoms Understanding Bupropion: Types, Uses, and Evidence | Philadelphia Integrative Psychiatry Bupropion Hydrochloride Tablets, 150 mg at ₹ 143/stripe in Mumbai | ID XL Smoking Cessation Instructions Naltrexone And Naltrexone - Bupropion Combination Australia How Long Does It Take To Stop Smoking With Wellbutrin Reddit Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Be sure to keep all appointments for office visits with your doctor. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; anxiety or panic attacks; difficulty falling asleep or staying asleep; aggressive, angry, or violent behavior; irritability; acting without thinking; severe restlessness; abnormal thoughts or sensations; feeling that people are against you; hallucinations (seeing things or hearing voices that do not exist); feeling confused; frenzied abnormal excitement; or any other sudden or unusual changes in behavior. The combination of dextromethorphan and bupropion is not approved for use in children under 18 years of age. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide.